Bio-Scriptives

Wholesale Pricing

How it works

Menthol, one of the ingredients inExtreme^PR, has been shown to be an effective pain reliever and does not carry the risks and side effects associated with orally taken ibuprofen, acetaminophen, or aspirin, such as stomach bleeding and negative interactions with other medications.

The multi-layeredExtreme^PRformulation works in part by using menthol to replace the pain sensations with a cooling feeling to provide temporary relief from localized pain. When applied to the skin,Extreme^PR’s ingredients are delivered deep into the skin with Derma-Release technology, allowing the menthol to stimulate certain nerves that perceive cold, while depressing those perceiving pain.

Aside from its increased safety profile, Extreme^PR can also be more effective than supplements commonly used for pain relief. For example, in a study published in the New England Journal of Medicine, glucosamine and chondroitin sulfate, two dietary supplements often advocated for joint pain, were no better at treating mild pain than an oral placebo (with no active).¹

Extreme^PRpenetrates quickly and completely leaving no obnoxious odor or greasy residue. It is convenient as taking a pill without the side effects of oral medication.

Dangers of oral pain medications

Many of the oral pain medications recommended by doctors and sold over-the-counter, including Tylenol, ibuprofen, and aspirin, can cause serious side effects and can lead to death. The common classifications of pain medications include:

• Non-Steroidal Anti-Inflammatory Drugs (NSAIDS), drugs such as Advil, Aleve, ibuprofen, naproxen, salicylates (aspirin), and Cox-2 inhibitors
• Acetaminophen (Paracetamol), the active ingredient in Tylenol products
• Opiate-based medications, such as Vicodin, Percocet, hydrocodone, oxycodone

The most widely quoted NSAID mortality estimates of 16,500 annual NSAID-related U.S. deaths come from the Arthritis, Rheumatism, and Aging Medical Information System (ARAMIS) database although a more recent study presented in the American Journal of Gastroenterology put the U.S. NSAID-related annual death rate closer to 5,000, including 1,600 deaths related to low dose aspirin.² Higher doses of aspirin or prolonged use at lower doses can also increase the likelihood of perforated ulcers and gastrointestinal bleeding, which are also the biggest known risks from taking NSAIDs. Cox-2 inhibitors, a type of NSAID, may increase cardiac risk (e.g., heart attack, stroke) at high doses as well.³

Acetaminophen does not fare much better as acetaminophen-related liver injury is the leading cause of acute liver failure.⁴ Additionally, acetaminophen side effects cause an estimated 18,184 emergency room visits each year.⁵ Opiate-based medications, often given after surgery or a major accident, can also cause problems due to their addictive properties and can lead to potential overdoses.

1. Daniel Clegg, et al. (2006) Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis. The New England Journal of Medicine 354:8, 795-808. The study tested patients with pain from osteoarthritis of the knee and the primary outcome measure was a 20 percent decrease in knee pain. There was no statistical significance in patients with mild pain treated with the placebo versus those treated with glucosamine or chondroitin sulfate (500 mg of glucosamine hydrochloride three times daily; 400 mg of sodium chondroitin sulfate three times daily).
2. Byron Cryer, NSAID-Associated Deaths: The Rise and Fall of NSAID-Associated GI Mortality, The American Journal of Gastroenterology (2005) 100, 1694-1695.
3. Based on study (LINK: http://www.cancer.gov/cancertopics/factsheet/prevention/cox-2-inhibitors) done by the National Cancer Institute.
4. According to a study (LINK: http://www.ncbi.nlm.nih.gov/pubmed/16317692) published in Hepatology.
5. According to Dan Budnitz, Division of Healthcare Quality Promotion of the National Center for Preparedness, Detection, and Control of Infectious Diseases (2009).